Early American collections in the Kislak Center include both manuscripts and printed materials, with notable strengths including literature; travel and exploration narratives; Judaica; and music.
The Penn Libraries Latin American Collection includes a substantial collection of ephemera, books, and audiovisual materials from Central America, focusing on sources for political and social history.
Penn's libraries are home to a wide range of special and general collections related to the Holy Land.
Penn Libraries has a substantive Indo-Caribbean collection that strives to reveal histories, communities, and cultural expressions that have remained underrepresented in most research libraries.
The Robert and Molly Freedman Jewish Sound Archive is among the most important resources in the world for the study of Jewish culture, folklore, history, linguistics, and literature through the medium of sound.
The Sydney S. Keil Collection contains over 1,000 items from colonial Latin America, including books, pamphlets, broadsides, and maps. A particular focus of the collection is the religious history of Mexico in the colonial period. The collection was presented it to the Penn Libraries by Jeffrey D. Keil in memory of his father in 1986, and it continues to grow thanks to an endowment.